Fear and Loathing in Las Vegas1998

Previous attempts to adapt the book into a film included Jack Nicholson and Marlon Brando as Duke and Gonzo. At one point, Dan Aykroyd and John Belushi were considered for the duo; John Cusack was also almost cast. Animator/filmmaker Ralph Bakshi, Martin Scorsese, and Oliver Stone all tried unsuccessfully to direct an adaptation. Thompson met Depp and was convinced no one else could play him. Filmmaker Alex Cox was eventually hired to direct with Depp and Del Toro committed to starring in the film, but the filmmaker had "creative differences" with Thompson over the script treatment as documented in the documentary Breakfast with Hunter. Gilliam was subsequently hired and made the film with the writer's approval.

Fear and Loathing in Las Vegas was a box office failure, grossing US$10.6 million at the North American box office, well below its $18.5 million budget. It has since become a cult film due in large part to its release on DVD, including a Special Edition released by The Criterion Collection.

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